Predicting a 50x profit in 2024 is highly speculative, but here are some top coins that have potential for significant growth:

1. Bitcoin #BTC As the largest cryptocurrency, Bitcoin has the potential to continue its upward trajectory, driven by mainstream adoption and limited supply.

2. Ethereum #ETH - With its transition to proof-of-stake (PoS) and growing DeFi ecosystem, Ethereum has significant potential for growth.

3. Solana #SOL - Solana's fast transaction times and low fees make it an attractive option for developers and users, potentially leading to significant growth.

4. #Polkadot #DOT - As a decentralized platform enabling interoperability between blockchains, Polkadot has potential for significant growth as the blockchain ecosystem expands.