A coin friend, born in the 2000s, has been staying up late for a long time. When he gets up every afternoon, he can only eat 3 bites of food and has symptoms of loss of appetite. His body is in a sub-healthy state for a long time. This kind of work and rest that overdraws life will sooner or later harm you.

Harvard Medical School in the United States published an important study in the Cell Journal. The results showed that the problem of staying up late for a long time is not in the brain or heart, but in the intestines.

Brother Fuli's intestines had problems in 2021, which has been 3 years. Staying up late for a long time will indeed give warnings. The initial symptoms are constipation, loss of appetite, bowel sounds, and sometimes pain in the intestines.

The reason why staying up late for a long time causes premature death is due to the accumulation of oxides in the intestines. Moreover, the researchers further confirmed through experiments that by actively removing oxides in the intestines of animals, even if they stay up late for a long time, their lifespan is no different from that of animals that maintain a normal work and rest schedule.

Staying up late will cause a large amount of oxides to be produced in the intestines, and reactive oxygen species (ROS) will accumulate in the intestines. ROS is a general term for a class of active oxygen-containing compounds produced by aerobic metabolism of organisms, mainly including hydrogen peroxide, superoxide anions, hydroxyl free radicals, etc.

ROS can damage DNA and other components of cells in large quantities. ROS can also destroy cell membranes, making cells unable to absorb nutrients from the outside, leading to cell death, aging of tissues and organs, and even inducing more than 200 diseases such as cardiovascular diseases, neurological diseases and tumors.

Insufficient sleep and circadian rhythm disorders can lead to intestinal barrier dysfunction and intestinal flora disorders, leading to the accumulation of ROS in the intestine, causing oxidative stress and cell damage, which is the key to causing metabolic dysfunction and further inducing sudden death.