Some of the best coins to consider buying today, with potential for gains in the short or medium term, include:

1. **Ethereum (ETH)**: Ethereum continues to be a strong contender due to its large ecosystem and ongoing upgrades, such as the shift to Ethereum 2.0 and layer-2 scaling solutions. With DeFi and NFTs thriving on its platform, ETH remains a solid investment for future growth.

2. **Solana (SOL)**: Solana has shown strong recovery potential and is favored for its high-speed, low-cost transactions, making it attractive for DeFi and NFT projects. If market sentiment improves, SOL could see significant upward movement.

3. **Avalanche (AVAX)**: Known for its speed and scalability, AVAX continues to be a competitor in the DeFi and NFT space, with recent ecosystem expansions making it a strong buy for potential growth.

4. **Chainlink (LINK)**: With its role in providing decentralized oracles for smart contracts, Chainlink is expected to see more adoption as blockchain projects continue to grow. Its strong fundamentals make it a potential buy-and-hold asset.

5. **Sui (SUI)**: Sui is a newer, high-performance blockchain project that focuses on scalability, which could attract long-term interest from developers and investors.

Always consider the overall market conditions, such as Bitcoin’s dominance and macroeconomic factors, before making an investment [oai_citation:2,Today's Top Crypto Gainers and Losers in Real Time](https://www.tradingdigits.io/gainers-and-losers) [oai_citation:1,Top Crypto Gainers and Losers Today | CoinGlass](https://www.coinglass.com/gainers-losers?type=2). Be sure to research each project’s fundamentals, as well as current news and trends, to make informed decisions.