Predicting the most profitable coins for 2024 involves speculation, but based on current trends, the following five coins could be strong contenders:

1. **Ethereum (ETH)**: Continued dominance in DeFi and smart contracts.

2. **Solana (SOL)**: High-speed transactions and growing ecosystem.

3. **Polygon (MATIC)**: Leading Layer 2 solution for Ethereum scalability.

4. **Avalanche (AVAX)**: Gaining traction with its fast and low-cost network.

5. **Chainlink (LINK)**: Essential for DeFi projects through its oracle services.

These coins have strong fundamentals, but always conduct your own research.