According to ChainCatcher, after Biden announced his withdrawal from the race, Johnson, the Republican speaker of the U.S. House of Representatives, called on Biden to resign "immediately." Johnson said in a statement, "If Biden is not fit to run for president, he is not fit to be president. He must resign from the presidency immediately." Johnson said that more than 14 million Americans chose Biden as the Democratic presidential candidate, but the party that calls itself the "Democratic Party" declared their votes invalid. As speaker of the House of Representatives, Johnson ranks second in the presidential succession order, second only to Harris.

When asked about calls from some congressional Republicans for Biden to resign as president, the White House said Biden "looks forward to completing his term." Senate Republican leader McConnell also accused the Democrats of "trying to subvert the will of the American people expressed in primaries across the country" in a statement, but did not call for Biden to resign as president.