Coinbase Premium, a key indicator of Bitcoin's price differential between Coinbase Pro and Binance, reflects U.S. investor sentiment. A higher premium signals robust buying pressure from U.S. investors, particularly institutional ones who predominantly use Coinbase. Recently, the premium turned negative but quickly rebounded following a sharp price drop. Historically, a negative premium often precedes market rebounds. This pattern suggests that U.S. institutional investors may capitalize on panic selling by smaller investors on Binance, adopting aggressive buying strategies to leverage market opportunities.