The Dow Jones Industrial Average fell by 0.9%, or 280.83 points, to 31,874.57, as concerns over a banking crisis in Europe pressured the broader market.
The S&P 500 dropped 0.7% to 3,891.93, while the Nasdaq Composite rose 0.05% to 11,434.05.
The Swiss central bank's announcement that it would provide liquidity to Credit Suisse if necessary helped the indexes regain some ground in afternoon trading.
Credit Suisse's U.S.-listed shares fell by nearly 14% after it revealed "certain material weaknesses" in its internal controls over financial reporting for the years 2021 and 2022.
The financial sector's crisis has centered around regional banks in recent days, and the big banks saw declines in sympathy with Credit Suisse and the European Bank sector.
Tulkot
On Wednesday, the Dow Jones Industrial Average closed more than 250 pts down as the banking crisis
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