We are currently in an era where cryptocurrency intersects with scientific research, the concept of DeSci (Decentralized Science) is emerging. Is the combination of DeSci and memes attracting capital inflow a good development? This article explores whether DeSci truly needs meme coins, along with their potential market impact and innovation opportunities. This article is based on a piece by NingNing, organized and translated by PANews. (Background: The founder of BIO Protocol announces three new DeSci projects, interpreting the value of decentralized science.) (Background supplement: The DeSci track surges, with detailed explanations of the decentralized science potential backed by Binance investment and CZ.) Does DeSci need meme coins? Do meme coins need DeSci? Can DeSci really become a disruptive innovation like DeFi? During this time, lurking in the unconscious abyss of on-chain PVP, I have observed the unfolding and interpretation of the DeSci narrative in the phenomenon realm: From the imitation of http://Pump.fun Pump Science launching longevity drugs $RIF and $URO meme coins for on-chain PK, to @0xAA_Science igniting the attention war surrounding Scihub-related memecoins, and then to OG DeSci projects like Bio Protocol, Vita DAO, and ResearchHub blooming anew. Finally, when the market thought the DeSci narrative was becoming a thing of the past, Andrew Kang called out with a narrative: 2024 DeSci = 2019 DeFi. "Open-source scientific papers," "restructuring the normalization of scientific research," and other fantastic new narratives have visibly excited many individuals crossing the realms of scientific research and the crypto sphere. For those of us who have been immersed in leftist ideology for years without realizing it, meme coins with positive externalities feel justly fulfilling. But the question is, do meme coins genuinely need positive externalities like DeSci? I tend to agree with Toly and crypto Boda's perspective; meme coins do not require positive externalities. Their primary essence is the internet lottery of the 2020s, selling extreme volatility to young individuals fantasizing about overnight wealth, offering Gen Z newcomers a chance to participate in wealth distribution. Assigning high-end value and meaning to a lottery ticket is the approach taken by China's sports lottery and welfare lottery. By doing so, it ultimately attracts many clueless individuals to pay an IQ tax, merely fattening the wallets of the house (the dealer) without any real positive externalities. However, another fact is that meme coin trading is a typical attention-tokenized market, following the laws of communication. A good narrative (whether it is a positive externality narrative or a cult culture) is a good community media-driven meme virus. From this perspective, DeSci is quite good, as it represents a conspiracy of honor in the market. So, does DeSci need meme coins? To be precise, does DeSci need the wealth effect and market attention brought by meme coins? The answer is affirmative. As a niche track, although backed and invested by institutions like Coinbase, Binance, Pfizer, as well as endorsements from Brain Armstrong, CZ, and Vitalik, DeSci projects have always been viewed by the market as social currencies for the elite circle (a need for show-off) and are not favored or allocated by mainstream market funds (who still remembers Celo's ReFi narrative in the last cycle?). In the end, can DeSci truly become a disruptive innovation like DeFi? There is a glimmer of hope. Here, I quote Popper's philosophy of science: science is not only about truth but also about power, and it is a religious power of the scientific community that particularly emphasizes the lineage and academic lineage. Whether it is research DAOs, Pump Science, or the pirate-style plundering mentioned in Toly's tweet, they are all trying to challenge and innovate the existing power structures of the scientific community through new organizational methods, new fundraising standardizations, and new collaboration methods. Although it is a small spark, it can provide warmth and hope on a cold winter night. But to be honest, DeSci does not have the high financial attributes of DeFi, lacking combinability (like LEGO) and the two tools of circular leverage; DeSci finds it challenging to create new assets worth 100 billion out of thin air like DeFi did back then. Related reports: CZ and Vitalik shout out! Biological science meme coins soar a thousandfold, hot money floods into the DeSci decentralized science track. BIO Protocol token raises over 11 million USD to accelerate decentralized science (DeSci) funding. What is the DeSci project "GenomesDAO" newly invested by Pantera? Analysis of development and features. "The DeSci decentralized science track is hot, but does it really need meme coins?" This article was first published on BlockTempo, the most influential blockchain news media.