To conduct a more detailed analysis of 'Decentralized Science (DeSci)' and incorporate critical thinking, we need to explore its potential, challenges, and how it can redefine the current and future state of scientific research. The following is a gradually expanded discussion:

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  1. What is decentralized science (DeSci)?


DeSci (Decentralized Science) is a concept aimed at reshaping scientific research, collaboration, and funding models through blockchain and Web3 technologies. Its core goal is to make science more open, transparent, and democratic, and to overcome institutional bottlenecks in traditional science through technological innovation.


Core issues

The traditional scientific system faces the following problems:

• Unfair funding distribution, with scientific research heavily reliant on government and a few private funds.

• Centralization of data and intellectual property restricts the dissemination of academic achievements.

• The academic publishing model is expensive and inefficient, leading to slow dissemination of innovation.

• Lack of diverse participation, with non-mainstream research topics and marginalized communities' voices being overlooked.


DeSci attempts to address these issues through DAOs (Decentralized Autonomous Organizations), the transparency of blockchain, and the introduction of token economics.


  1. Core issues and challenges of traditional science


2.1 The 'Valley of Death' problem


The 'Valley of Death' is a major dilemma in the scientific community, referring to the gap between basic research and applied development. Even promising projects may stagnate due to a lack of leapfrog support.


Critical analysis

  • Current shortcomings: Traditional funding institutions tend to support lower-risk research, limiting bold innovative attempts.

  • The potential of DeSci: Through decentralized crowdfunding, DeSci can allow individual investors worldwide to directly fund projects they believe in. However, how to ensure efficient use of these funds and prevent scams still requires the introduction of reasonable governance mechanisms.


2.2 Issues in academic publishing and intellectual property


Disadvantages of the publishing system

  • High costs: The open access publishing model requires researchers to pay substantial fees to ensure papers are freely accessible, which many researchers, especially those in developing countries, find difficult to bear.

  • Inefficiency and bias in peer review: Peer review often leads to publication delays and may involve conflicts of interest or subjective biases.

  • Centralization of intellectual property: Universities or research institutions strictly control patent ownership, limiting the sharing and application of research results.


Countermeasures of DeSci

  • Open platforms: Blockchain-based open science platforms (like ResearchHub) can reward contributors with tokens, encouraging data and result sharing.

  • Tokenization of intellectual property: By tokenizing patents and papers through NFTs (non-fungible tokens), researchers can decide independently how to use them and the economic returns.


Potential issues

  • Limitations of Tokenization: The value of NFTs is closely related to market fluctuations, which may lead to an excessive commercialization of scientific research.

  • The contradiction between openness and privacy: Certain research data is highly sensitive, and complete transparency may raise ethical or security issues.


  1. Innovations and limitations of DeSci in funding issues


3.1 Traditional funding dilemmas


  • Cumbersome application processes: Researchers often need to spend months preparing funding applications, whereas this time could be used for actual research.

  • Concentration of funding sources: Many studies are funded by large pharmaceutical companies or governments, which may lead to explicit or implicit control of research directions by funding sources.


3.2 Solutions of DeSci


  • Token economics: Researchers can attract investor support by tokenizing their research projects or intellectual property. For example, IP-NFTs provide early funding to researchers and allow investors to share in future intellectual property revenues.

  • DAO governance: Decentralized autonomous organizations allocate research funding through community voting, avoiding potential bureaucracy and bias issues of traditional institutions.


Case study: Molecule Protocol

Molecule connects researchers and investors through IP-NFTs, creating a new ecosystem for biotechnology financing. However, Molecule's model needs to address the following issues:

  1. Investor education: Ordinary investors may lack knowledge in the biopharmaceutical field, leading to inefficient funding distribution.

  2. Long-term return mechanisms: The return cycle of scientific research is usually long, which may conflict with investors' short-term profit expectations.


3.3 Roles and limitations of DAOs in DeSci


DAOs provide the core structure for DeSci, offering a more democratic research support model through decentralized voting and governance mechanisms.


4.1 Advantages of DAOs


  • Decentralized governance model: Community members can collectively decide on funding allocation and project direction, reducing the intervention of a single institution.

  • Global participation: Anyone can participate in DAO governance, regardless of their geographic location or economic background.


4.2 Challenges of DAOs


  • Governance efficiency: Decentralized decision-making may lead to inefficiencies, especially when quick responses are needed.

  • Risk of power centralization: Although DAOs aim for decentralization, the concentrated holding of governance tokens may still lead to de facto centralization.


Case study: VitaDAO and AthenaDAO

  • VitaDAO: Focused on longevity research, funding early projects through distributed governance. However, its operational model still faces the challenge of attracting non-traditional investors.

  • AthenaDAO: Focuses on women's health, filling a significant gap in traditional medical research. However, whether women's health research can attract sufficient community support is a key challenge for its future development.


  1. Critical summary


Value and prospects of DeSci


  • DeSci indeed provides the potential to address key pain points in scientific research through technological innovation, such as data sharing, funding efficiency, and academic openness.

  • Its emergence facilitates broader participation, giving voice to non-traditional scientific contributors.


Concerns and improvement directions of DeSci


  • Funding and governance transparency: While decentralization can increase transparency, overly complex mechanisms may alienate ordinary users.

  • Potential speculation of token economics: Scientific research requires long-term investment, while the short-term fluctuations of the token market may conflict with scientific goals.

  • Technology acceptance: Not all researchers are familiar with blockchain technology or willing to adopt this new model; how to achieve broader education and promotion is key.


Final outlook


Decentralized science is an exciting direction that may bring greater efficiency and equity to the scientific community. However, its future success depends on balancing technology, ethics, and governance. Whether DeSci can transition from ideal to practice hinges on how to continuously optimize technological tools and governance models to ensure that the original intent of science is not obscured by excessive commercialization.