The three major U.S. stock indices opened mixed, with the Dow opening down 0.24%, the S&P 500 opening up 0.23%, and the Nasdaq opening up 0.29%. Cryptocurrency concept stocks opened lower across the board, with MicroStrategy (MSTR.O) down 5.9%, Coinbase (COIN.O) down 3.9%, and Riot Blockchain (RIOT.O) down 5.1%.