According to Deep Tide TechFlow, on December 31, Coinbase Ventures head Hoolie Tejwani stated in an interview with The Block that the company expects to be "very active in 2025 and beyond" and is prepared to seize market opportunities. Coinbase Ventures is optimistic about constructive regulatory progress in the U.S., believing that the pro-cryptocurrency Donald Trump administration and the new Congress will drive this process.

Tejwani pointed out that Coinbase Ventures will continue to invest broadly in the on-chain economy, focusing on the "time and energy invested by the best and brightest builders." The company is optimistic about the development of the application layer, believing that the maturity of infrastructure makes applications at internet scale feasible, with a focus on stablecoin payments, the intersection of finance and crypto AI, on-chain consumer applications (such as social, gaming, and creator applications), and DeFi innovations. Meanwhile, Tejwani stated that Coinbase Ventures has not completely abandoned the infrastructure layer, as there are still unresolved challenges and new opportunities in the tools space.