I understand that the biggest difference between on-chain assets (meme) and secondary altcoins is not whether there is VC involvement.
The biggest difference is:
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There are multiple value discovery processes
Scanning the chain
Alpha small group / large group
First batch of calls on Twitter
Funds pouring into the secondary market
BN/OK perpetual list
BN/OK sports list
Secondary logic/gaming
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Community participation in value creation
Secondary altcoins basically do not have a community;
On-chain asset communities directly participate in value creation:
Narratives; community secondary creation; community activity; traffic dissemination; community operations, etc.
Currently, the on-chain 'project coins',
Actually satisfy the first point, there are multiple value discovery processes;
AI memes are more closely related to the community, with community participation in the value creation process;
Some targets in DeSci, due to their relevance to biomedicine, are mainly led by the project party, and there seems to be no second stage of community participation in value creation.