I invested heavily in GOAT at 200 million, and in PNUTS after it was listed on Binance at 350 million, and both times I gained a lot.
This time I saw the DeSci track very early, but entered the market a little late. After all, intuitively I felt that this track was "just another one to ride on the popularity" - we in the cryptocurrency circle are riding on the popularity every day, and we have long been immune to the general trend. This is a crazy and stupid market. The official community tweets a picture and can reap a lot of benefits. It seems that you won't miss anything if you don't study it.
However, precisely because it is difficult to understand, it still fits the saying I often say, "Those on the bus don't understand, and those who understand haven't gotten on the bus yet." Hard to understand does not mean impossible to understand. I will explain it to you in 10 minutes. After reading it, perhaps you will be like me and can only say two words: WTF!
1. DeSci Background
DeSci, or decentralized science, uses blockchain technology to break down traditional barriers in scientific research. In the past, scientific research took a long time to monetize, and faced problems such as funding shortages, uneven resources, and poor sharing of results.
Ordinary people cannot see it, but CZ is at a high level and knows that there are many geniuses here who lack an opportunity and support. The high speculation of blockchain gave DeSci an opportunity to develop - just like the development of the United States, which is inseparable from Wall Street, a market full of speculation, which started under the sycamore tree. The essence of the stock market is to use the speculative market to promote the realization of value.
The combination of DeSci and the cryptocurrency world actually complements each other: the cryptocurrency world is highly speculative, and everyone loves money; while the scientific research world is zero-speculation, and everyone works hard, but may not achieve any results for decades. Countless talents contribute silently, but lack funding and support. What if the two are connected? Those who love money work for money and support their ideals; those who love science get money to use and gain the momentum for development.
When DeSci makes science more prosperous, scientific research results will change the world, and the profits generated in turn can feed back to the cryptocurrency circle, whether it is to attract the attention of the mainstream circle, or to enable speculation within the circle through a steady stream of outside profits - making token issuance valuable is very beneficial.
These logics have not received much attention. After all, how can they be realized? Is it just another round of nonsense?
2. Several major clues
Several seemingly independent but closely related events have occurred recently:
1. Binance announces exclusive investment in BIO Protocol
This is a DeSci protocol, a technology company. The purpose of the establishment of this protocol is to use blockchain technology to change the financing and commercialization methods of early scientific research. Early scientific research financing? The cryptocurrency circle is not short of money, so how can the commercialization methods change? Let's see what Binance Labs says. They say, "BIO can be regarded as the Y Combinator of on-chain science," and Y Combinator is the world's most powerful incubator. The total value of its 100 startups with the highest valuation or market value exceeds 100 billion US dollars, including Airbnb, Coinbase, Stripe, Reddit, etc.
In contrast to the current system that relies on central institutions for research and funding, Decentralized Science, or DeSci, aims to capture research investments through crowdfunding initiatives and decentralized ownership.
The BIO Platform enables scientists, patients, and investors around the world to fund, develop, and co-own new medicines through a biotech DAO, filling gaps in traditional science funding, particularly in areas such as rare diseases, longevity, and emerging health challenges.
BIO's existing network consists of seven "BioDAOs" running on the Ethereum blockchain. A spokesperson said it plans to expand to Solana and other blockchains in the first quarter of 2025. These DAOs are fundamentally different from traditional DAOs in the cryptocurrency world. For example, its VitaDAO is dedicated to funding and advancing early longevity research and is supported by the venture capital arm of global pharmaceutical company Pfizer. It is currently studying longevity and cancer prevention.
Pfizer's current market value is $145 billion, which is at the same level as OpenAI, which was valued at $150 billion in its latest round of financing.
2. CZ’s new direction: AI and biotechnology
After CZ was released from prison, he was interviewed about his future direction. His original words were: "Now I mainly do two things: one is Google Academy, and the other is investment. The investment is mainly concentrated in the three fields of blockchain, artificial intelligence and biotechnology." (The original text is at the end of the article)
It is natural to invest in blockchain here, and artificial intelligence and biotechnology are worth noting here. Artificial intelligence may refer to traditional AI, and it will definitely include the combination of AI and artificial intelligence. Binance has already launched ACT.
So what biotech stocks are worth paying attention to? Which one is the leader? Let’s put it aside for now and see the details later. Let’s first look at CZ’s movements.
On November 13, Binance founder CZ posted on the social platform X, "Learning at a small DeSci entrepreneur gathering organized by Binance Labs," and attached a photo of himself and Vitalik.
(In the picture, between CZ and V God is CMO from the media followin, it seems that this party is not so "small").
At the event, Buterin also showed CZ VitaDAO’s first longevity product, VD001, a natural high-dose spermidine supplement approved by the Thai FDA. CZ said frankly that he “hopes to see 1,000 Desci projects next year.”
3. Binance’s official account issued a DeSCi research report to clarify its name
It mainly discussed what decentralized science is and listed several examples: including academic publishing, research funding, data sharing and collaboration, etc.
What this reflects is Binance’s attention to this track - Binance’s research reports are generally strongly correlated with Binance’s listing of coins.
The original research report is here: https://bit.ly/bnrif
So, where are the opportunities for DeSCi and which target should he speculate on?
3. DeSCi's main line
This wave of DeSCi's popularity actually has a traceable cause. The cause is the movements of CZ and Binance mentioned earlier. Therefore, to speculate on DeSCi, you must grasp the main line and understand the main contradiction, that is: hold on to Binance and CZ.
The main lines here are briefly sorted out, which actually include:
1. Bio protocol invested by Binance
This has gone through two rounds of fundraising before, raising 33 million yuan in funds. I also participated in the second round, but this is actually the value coin of the protocol. It is still too early to list the coin, and it will be normal to list it on Binance in the future.
Since there is no other opportunity, let’s put it aside for now.
2. Bio Protocol Sub-DAO
The most well-known of these is vitaDAO (the bio protocol itself was also created by vitaDAO members). In order to promote DeSCi, the bio protocol set up a coin issuance platform called pump.science.
This coin issuance platform is completely different from pump.fun. It is not something that can be issued whenever you want, and it is not something that can be issued randomly. Instead, it must be strongly related to scientific experiments. So far, there are only two projects, one called $rif and the other called $uro, both of which are life sciences that cz focused on above.
Behind these experiments is Pfizer, which has invested in Vitadao, a global pharmaceutical giant with a market value as high as OpenAI.
The progress of these two experiments are synchronized on the website and are strongly correlated with the tokens.
Therefore, it is still too early for the platform’s third coin, and it all depends on the experiments. However, we can make a prediction that there may be countless new drugs coming out on the platform in the future, but the ones that will receive the most attention from the coin level will be $rif and $uro; there should also be sustained advantages in terms of research and development progress.
$rif Antibiotics have long been the most extensive and important area of research in the treatment of tuberculosis and other bacterial infections.
$uro is a metabolite extracted from pomegranates and other fruits, known for its potential life-extending properties. It is also the focus of Vitalik Buterin and all the big guys.
The pump contract addresses of these two tokens are:
Since Vitalik and CZ showed up on the aggregation platform to show their support, the two tokens have received a lot of attention and quickly became popular. But a bunch of related DeSCI representatives also came out immediately - that's how the cryptocurrency world works, once an animal becomes popular, all its relatives will be dragged out and hyped.
At this time, it becomes important to understand the evolution of DeSCI and some marginal information.
3. BIO protocol related
Binance invested in the bio protocol, aiming to promote the combination of science and blockchain through it, and the bio protocol incubated pump.science.
Regarding the attitude of the BIO protocol. On the Twitter of the protocol founder, https://x.com/paulkhls, there is a lot of information worth noting. For example, he warned of risks, and now there are hundreds of "desci" tokens emerging. He mentioned that "real science is difficult to put on the chain, don't just issue coins, we will do our best to protect users and scientists, and build and create a permissionless platform for patients."
Last week, he held a "mini conference" on biotechnology in Bangkok. The guests who attended were all very impressive, so his opinions should also be paid special attention to to a certain extent.
The essence here is to create a financial market for science, just like building a Wall Street for the United States, both of which are driven by speculation to realize value.
If you understand these essences, you will not be easily led astray. For example, some people in the cryptocurrency circle go to publish a certain symbol and contract, hoping to get confirmation and hype; some people start to constantly find angles and issue coins in the name of science, which may be a good thing, but you must not be led astray by the main line of this wave of DeSCI. Losing money is a small matter, but missing the main line is a big matter.
4. A wonderful space
In the official space of pump.science on the 17th, the official mentioned a lot of explosive content, such as one paragraph saying:
***
We want to build the product the right way, do human trials, give people Uro, and test wearables or use data from wearables to see if they can actually increase lifespan.
Biomarkers like VO2 max, heart rate or heart rate variability, etc. These are all different metrics that wearables like the Apple Watch and Whoop track. We wanted to see if the Uro could actually improve these human metrics.
Our goal is to sell this supplement to people. All revenue from the supplement sales will be used to buy back and burn tokens. You can imagine that someone goes to the store to buy Uro, and any profit will be used to buy back and burn tokens, forming a cycle.
***
At the meeting in Bangkok, Vita displayed a bottle of biological supplement VC001, which is a product from vitaDAO. It is a natural high-dose spermidine supplement approved by the Thai FDA. It should be natural for the RIF and URO that vitaDAO is researching to go to market.
If a drug is successful in the future and is put on the market, part of the final profit will be used to repurchase tokens and destroy them. This vision instantly makes the pump.science platform different. If blockchain can support biotechnology and eventually have good new drugs listed on the market (not necessarily these two today, but many in the future), this will become a very powerful channel to connect web2 and web3, allowing speculation to create value and support the development of the most important areas.
Wall Street, which originated under the sycamore tree, is a holy land of speculation and was born for speculation, but the capital flow generated by speculation has supported the greatness of the United States, which is similar in nature.
In this space, the official also mentioned why they used the meme method. They said that they consulted experts in economic models and finally selected this method as the best. They also mentioned doge, etc. I can't help but wonder where these experts come from. Considering that Binance is deeply involved in the economic models of investment projects, especially this is the area that CZ pays most attention to, then there is reasonable suspicion.
You can listen to the original recording on the official Twitter account for details.
4. Desci’s Target
The best targets at the moment are $rif and $uro. In addition, there are some other targets worth paying attention to, which are described here one by one.
1. Leading $rif and $uro
There is no doubt about this.
As the leader of the new track, people will compare it with aimeme. Aimeme is weakly associated with openai, which has a market value of about 150 billion. Descimeme is associated with Pfizer, which also has a market value of about 150 billion, but has directly invested in vitaDAO where $rif and $uro are located, and has attracted more attention.
The driving force behind the scenes, the popularity of aimem was triggered by the $50,000 investment from a16z, while the popularity of desci was caused by cz and binance. I think there should be no doubt that the latter crushes a16z in terms of power.
Science and AI are similar in a broad sense, both of which are things that change the world. However, compared with AI's financing fomo, science needs blockchain more.
2. Possibility of listing on Binance
In addition to the background mentioned above, readers should have a general idea of it.
What is more important is what Binance wants. Compared with Binance, what are the transaction fees and even the coin listing fees that everyone is arguing about? These are actually trivial things and not worth mentioning. What Binance cares about is the development and expansion of the industry, which is its lifeline.
The memes in the cryptocurrency world are very popular now, which actually highlights the weakening of value. However, if the cryptocurrency world is only memes, it will not be good for the industry or Binance. Yijie also said in an interview that she hopes to see more projects that create value.
In fact, Vitalik Buterin's attitude towards Meme has also changed a lot. In his latest opinion, he said a classic sentence, "People come for money and stay for ideals." How to stay for ideals? I think the combination of meme and value is the key.
So in terms of Binance's expectations, considering all factors, it is actually quite large.
3. Analysis of coin holding addresses
Relatively speaking, the proportion of the front row of coin holding addresses is not high, and the laundering has been going on for a long time. The strong dealer behind it should have obtained enough chips (if there is a strong dealer^^).
The dispersion is quite high, which is a big advantage. The top 10 accounts for a relatively small proportion, after all, it has been washed for a long time.
4. Wide spread
Science + meme is easy to understand at first glance, but if it is changed to the life science of immortality, it sounds easy to spread.
In fact, most people haven’t had time to take a closer look at what this thing is, which is why I got up early in the morning to write such a popular science article.
Basically, if you understand it, you will feel like I do that this track has greater potential than ai+meme.
Speaking of which, the opportunities in the cryptocurrency circle have not changed in recent years. Just follow Vitalik Buterin, Elon Musk, and Binance, right?
V. Other Subject Matters
In addition to these, there are other coins that you can pay attention to. They can be divided into two categories: one is the orthodox value coins, and the other is a bunch of free-riding coins that emerged after RIF became popular.
1. Value Coin
Because of the token distribution and economic model, I have a feeling that value coins may not be very popular. Their advantage over memes may be that they are relatively stable, but their disadvantage is that the community may not buy into them.
There are several main labels, including bio, vita, rsc, etc.
bio is a Binance investment, which is a key focus, but it is not available for purchase at the moment.
vita is the token of Vitadao, with a market value of 24 million and a total circulation of 170 million. The two most popular memes were created by him, but this coin may not be listed on Binance. After all, Meme is king, and Binance is investing in the bio protocol.
The contract is
0x81f8f0bb1cB2A06649E51913A151F0E7Ef6FA321
Rsc, this is also science related, related to the founder of Coinbase, etc., 780 billion in circulation, market value 800 million! A bit high, just posted to let everyone know (after all, Coinbase has almost no wealth effect on value coins)
0xd101dcc414f310268c37eeb4cd376ccfa507f571
This wave is also mainly led by Binance, and Coinbase has nothing to do with it. The difference between Coinbase and Binance is that there is no soul figure like Yijie. Everything is done in a businesslike manner and there is no chance to lead anything.
2. Other meme coins
When something becomes popular, a bunch of imitations will come out, and there are dealers everywhere in the currency circle. This is normal. Some of them are using the name, and some are waiting for the picture. Personally, I usually only pay attention to the strongest leaders, but I will share them with you for a comprehensive view.
The reason for focusing on the leader is not personal preference, but investment experience:
When a new track or new concept appears, people will always quickly look for new things with lower market value and similar concepts - especially those who are interested will also quickly launch new dishes. However, the first or leading one in a new track or new concept is the best, and those who speculate on it often gain the most (except for the banker).
For example: $ordi of brc20
Musk's $doge
$pnut of the concept of saving the nation
$goat by aimeme
Monument Concept $luce
$rif of desci
Wait, because I have a principle, that is, I almost never participate in anything that can be issued by the running water dealer, and only participate in things that ordinary people can't make.
Here are some corresponding coins:
The first one is Scihub
Scihub is the largest pirated paper site. It uses different methods to bypass publishers' paywalls and provides millions of academic papers and works without considering copyright issues. Some people think this is justice, but overall there is no dispute about the harm of piracy, so this website has been besieged by various countries.
This coin in the cryptocurrency circle has no direct relationship with this website. It’s just that some dealer saw that Desci became popular, so he immediately issued this coin, and then started organizing donations, etc. This is a good thing for the lady to get the money - but I am also a little worried that being caught up in this storm vortex, I don’t know if there will be more risks in the long run.
From a speculative perspective, where the final outcome will be depends on the dealer's control of the funds and the market manipulation, but I personally don't like this. There was an Assange DAO before, which seemed to be quite popular and also had a similar narrative of justice, but the ending didn't seem to be very good (I don't have a deep impression of it because I don't participate in this kind of thing.)
The second one is bio/acc
The one above is called bio/acc, with a market value of 3 million. It is also in the scientific track. The activity itself is very grand, but the relationship between this token and the official is not direct.
Of course, except for the rif and uro mentioned above, the others are not direct, so the list here may not be complete. If you have any other ones, please add them in the comment section.
However, I personally just focus on the main line. Regarding DeSCI, following Binance is the only choice.
Of course, in the end, I would also like to remind you of the risks. No one can know in advance whether Binance will be launched or when it will be launched, so please refer to it for yourself.
